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Article

Notch Signaling Is Necessary to Maintain Quiescence in Adult Muscle Stem Cells

1 Nov 2011

Abstract excerpt

Satellite cells (SCs) are myogenic stem cells found in skeletal muscle that function to repair tissue damaged by injury or disease. SCs are quiescent at rest, although the signaling pathways required to maintain quiescence are unknown. Using a transgenic Notch reporter mouse and quantitative reverse-transcription polymerase chain reaction analysis of Notch target genes, we determined that Notch signaling is...

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PMID: 22045613
DOI: 10.1002/stem.773

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