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Broadening the spectrum of ivermectin: Its effect on Trypanosoma cruzi and related trypanosomatids

28 Jul 2022

Abstract excerpt

Chagas disease is an endemic American parasitosis, caused byTrypanosoma cruzi. The current therapies, benznidazole (BZN) and nifurtimox (NFX), show limited efficacy and multiple side effects. Thus, there is a need to develop new trypanocidal strategies. Ivermectin (IVM) is a broad-spectrum antiparasitic drug with low human and veterinary toxicity with effects againstT. bruceiandLeishmaniaspp. Considering this and...

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PMID: 35967842
DOI: 10.3389/fcimb.2022.885268

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