Article
Extract from Asteraceae Brachylaena ramiflora induces apoptosis preferentially in mutant p53-expressing human tumor cells.
Carcinogenesis - 1 Jun 2010
Karimi Masoud, Conserva Francesca, Mahmoudi Salah, Bergman Jan, Wiman Klas G, Bykov Vladimir J N
Abstract excerpt
The p53 tumor suppressor gene is inactivated by point mutation in a large fraction of human tumors, allowing evasion of apoptosis and tumor progression. p53 mutation is often associated with increased resistance to therapy. Pharmacological reactivation of mutant p53 is an attractive therapeutic strategy. We previously identified p53 reactivation and induction of massive apoptosis, a low-molecular weight compound...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.