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Implication of Epstein‐Barr Virus Infection in Disease‐Specific Autoreactive B Cell Activation in Ectopic Lymphoid Structures of Sjögren's Syndrome

28 May 2014

Abstract excerpt

OBJECTIVE: To examine whether the B cell tropic γ-herpesvirus Epstein-Barr virus (EBV) is aberrantly expressed in its latent and lytic forms within ectopic lymphoid structures (ELS) in the salivary glands of patients with Sjögren's syndrome (SS), and to investigate the relationship between EBV dysregulation, B cell activation, in situ differentiation of autoreactive plasma cells, disease-specific autoantibody...

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PMID: 24891330
DOI: 10.1002/art.38726

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