Article
Relationship of the FKBP5 C/T polymorphism with dysfunctional attitudes predisposing to depression.
Comprehensive psychiatry - 1 Aug 2014
Suzuki Akihito, Matsumoto Yoshihiko, Sadahiro Ryoichi, Enokido Masanori, Goto Kaoru, Otani Koichi
Abstract excerpt
FK506-binding protein 51 (FKBP5) is a co-chaperone of the glucocorticoid receptor, and plays an important role in the negative feedback regulation of the hypothalamic-pituitary-adrenal axis. The C/T single nucleotide polymorphism in the intron 2 of the FKBP5 gene affects cortisol secretion, and h...
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