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Article

Enhanced human receptor binding by H5 haemagglutinins

12 Apr 2014

Abstract excerpt

Mutant H5N1 influenza viruses have been isolated from humans that have increased human receptor avidity. We have compared the receptor binding properties of these mutants with those of wild-type viruses, and determined the structures of their haemagglutinins in complex with receptor analogues. Mutants from Vietnam bind tighter to human receptor by acquiring basic residues near the receptor binding site. They bind...

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PMID: 24889237
DOI: 10.1016/j.virol.2014.03.008

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