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Article

MuLV-related endogenous retroviral elements and Flt3 participate in aberrant end-joining events that promote B-cell leukemogenesis.

Genes & development - 1 Jun 2014

Johnson Radia M, Papp Eniko, Grandal Ildiko, Kowalski Paul E, Nutter Lauryl, Wong Raymond C C, Joseph-George Ann M, Danska Jayne S, Guidos Cynthia J

Abstract excerpt

During V(D)J recombination of immunoglobulin genes, p53 and nonhomologous end-joining (NHEJ) suppress aberrant rejoining of DNA double-strand breaks induced by recombinase-activating genes (Rags)-1/2, thus maintaining genomic stability and limiting malignant transformation during B-cell development. However, Rag deficiency does not prevent B-cell leukemogenesis in p53/NHEJ mutant mice, revealing that p53 and NHEJ...

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Identifiers

PMID: 24888589
DOI: 10.1101/gad.240820.114
PMCID: PMC4052764

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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