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Article

Probing water density and dynamics in the chaperonin GroEL cavity.

Journal of the American Chemical Society - 2 Jul 2014

Franck John M, Sokolovski Miri, Kessler Naama, Matalon Erez, Gordon-Grossman Michal, Han Song-I, Goldfarb Daniella, Horovitz Amnon

Abstract excerpt

ATP-dependent binding of the chaperonin GroEL to its cofactor GroES forms a cavity in which encapsulated substrate proteins can fold in isolation from bulk solution. It has been suggested that folding in the cavity may differ from that in bulk solution owing to steric confinement, interactions with the cavity walls, and differences between the properties of cavity-confined and bulk water. However, experimental...

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Identifiers

PMID: 24888581
DOI: 10.1021/ja503501x
PMCID: PMC4091268

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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