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Article

Polypeptide in the chaperonin cage partly protrudes out and then folds inside or escapes outside.

The EMBO journal - 1 Dec 2010

Motojima Fumihiro, Yoshida Masasuke

Abstract excerpt

The current mechanistic model of chaperonin-assisted protein folding assumes that the substrate protein in the cage, formed by GroEL central cavity capped with GroES, is isolated from outside and exists as a free polypeptide. However, using ATPase-deficient GroEL mutants that keep GroES bound, we found that, in the rate-limiting intermediate of a chaperonin reaction, the unfolded polypeptide in the cage partly...

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Identifiers

PMID: 20959808
DOI: 10.1038/emboj.2010.262
PMCID: PMC3020636

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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