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Article

Intratumoral distribution of EGFR mutations and copy number in metastatic lung cancer, what impact on the initial molecular diagnosis?

Journal of translational medicine - 16 May 2014

Mansuet-Lupo Audrey, Zouiti Fouzia, Alifano Marco, Tallet Anne, Charpentier Marie-Christine, Ducruit Véronique, Devez Fabrice, Lemaitre Fanny, Laurent-Puig Pierre, Damotte Diane, Blons Hélène

Abstract excerpt

BACKGROUND: Activating epidermal growth factor receptor (EGFR) mutations characterize a subgroup of non-small-cell lung cancer that benefit from first line EGFR tyrosine kinase inhibitors (EGFR-TKI). However, the existence of polyclonal cell populations may hinder personalized-medicine strategies as patients' screening often depends upon a single tumor-biopsy sample. The purpose of this study is to clarify and to...

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Identifiers

PMID: 24885034
DOI: 10.1186/1479-5876-12-131
PMCID: PMC4041917

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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