Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Understanding EGFR heterogeneity in lung cancer.

ESMO open - 1 Oct 2020

Passaro Antonio, Malapelle Umberto, Del Re Marzia, Attili Ilaria, Russo Alessandro, Guerini-Rocco Elena, Fumagalli Caterina, Pisapia Pasquale, Pepe Francesco, De Luca Caterina, Cucchiara Federico, Troncone Giancarlo, Danesi Romano, Spaggiari Lorenzo, De Marinis Filippo, Rolfo Christian

Abstract excerpt

The advances in understanding the inherited biological mechanisms of non-small cell lung cancer harbouring epidermal growth factor receptor (EGFR) mutations led to a significant improvement in the outcomes of patients treated with EGFR tyrosine kinase inhibitors. Despite these clinically impressive results, clinical results are not always uniform, suggesting the need for deepening the molecular heterogeneity of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Carcinoma, Non-Small-Cell Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ErbB Receptors

Share to Lung Cancer Treatments and Mutations

Share to Lung Neoplasms

Share to Mutation

Share to Protein Kinase Inhibitors

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 33067323
DOI: 10.1136/esmoopen-2020-000919
PMCID: PMC7569934

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Understanding EGFR heterogeneity in lung cancer.PMID 33067323Read ↗

The role of molecular heterogeneity targeting resistance mechanisms to lung cancer therapiesSemantic proximity Read ↗

Tumor Heterogeneity and the Immune Response in Non-Small Cell Lung Cancer: Emerging Insights and Implications for ImmunotherapySemantic proximity Read ↗

Heterogeneity in Lung Cancer.Semantic proximity Read ↗

Molecular heterogeneity in lung cancer: from mechanisms of origin to clinical implicationsSemantic proximity Read ↗

Intratumoral Cellular Heterogeneity: Implications for Drug Resistance in Patients with Non-Small Cell Lung CancerSemantic proximity Read ↗

[Advances of heterogeneity of EGFR in non-small cell lung cancer].Semantic proximity Read ↗

Non-Genetic Intra-Tumor Heterogeneity Is a Major Predictor of Phenotypic Heterogeneity and Ongoing Evolutionary Dynamics in Lung Tumors.Semantic proximity Read ↗

Intratumoral distribution of EGFR mutations and copy number in metastatic lung cancer, what impact on the initial molecular diagnosis?Semantic proximity Read ↗

Epidermal Growth Factor Receptor Mutations in Resectable Non-Small Cell Lung Cancer Patients and their Potential Role in the Immune Landscape.Semantic proximity Read ↗

Tissue Heterogeneity of EGFR Mutation in Lung AdenocarcinomaSemantic proximity Read ↗

Tumor Clonality and Resistance Mechanisms in EGFR Mutation-Positive Non-Small-Cell Lung Cancer: Implications for Therapeutic SequencingSemantic proximity Read ↗

Targeted therapy in non-small cell lung cancer: a focus on epidermal growth factor receptor mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.