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Article

Cisplatin-resistant cells in malignant pleural mesothelioma cell lines show ALDH(high)CD44(+) phenotype and sphere-forming capacity.

BMC cancer - 30 Apr 2014

Cortes-Dericks Lourdes, Froment Laurene, Boesch Ruben, Schmid Ralph Alexander, Karoubi Golnaz

Abstract excerpt

BACKGROUND: Conventional chemotherapy in malignant pleural mesothelioma (MPM) has minimal impact on patient survival due to the supposed chemoresistance of cancer stem cells (CSCs). We sought to identify a sub-population of chemoresistant cells by using putative CSC markers, aldehyde dehydrogenase (ALDH) and CD44 in three MPM cell lines; H28, H2052 and Meso4. METHODS: The Aldefluor assay was used to measure ALDH...

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Identifiers

PMID: 24884875
DOI: 10.1186/1471-2407-14-304
PMCID: PMC4021184

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