Article
Common variants of cGKII/PRKG2 are not associated with gout susceptibility.
The Journal of rheumatology - 1 Jul 2014
Sakiyama Masayuki, Matsuo Hirotaka, Chiba Toshinori, Nakayama Akiyoshi, Nakamura Takahiro, Shimizu Seiko, Morita Emi, Fukuda Nana, Nakashima Hiroshi, Sakurai Yutaka, Ichida Kimiyoshi, Shimizu Toru, Shinomiya Nariyoshi
Abstract excerpt
OBJECTIVE: Recently, genetic analyses indicated the association between gout and cGMP-dependent protein kinase 2 (cGKII/PRKG2) gene in a Fukien-Taiwanese heritage population. However, no replication study has been reported in other ancestries. Therefore, we investigated this association in a Japanese population. METHODS: Genotyping of 4 variants (rs11736177, rs10033237, rs7688672, and rs6837293) of cGKII was...
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