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Article

Association of CYP1A1, CYP1B1 and CYP17 gene polymorphisms and organochlorine pesticides with benign prostatic hyperplasia.

Chemosphere - 1 Aug 2014

Kumar Vivek, Banerjee Basu Dev, Datta Sudip Kumar, Yadav Chandra Shekhar, Singh Satyender, Ahmed Rafat Sultana, Gupta Sanjay

Abstract excerpt

It is well established that steroidal hormones (testosterone and estrogen) increase benign prostatic hyperplasia (BPH) risk. Cytochrome P450 (CYP) enzymes especially CYP1A1, CYP1B1 and CYP17 metabolize these hormones. Apart from that, several endocrine disrupting organochlorine pesticides (OCPs) are reported to mimic the activity of these steroidal hormones. Therefore, functional polymorphisms in these genes and...

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Identifiers

PMID: 24875910
DOI: 10.1016/j.chemosphere.2014.02.081

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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