Article
Human FABP1 T94A variant impacts fatty acid metabolism and PPAR-α activation in cultured human female hepatocytes.
American journal of physiology. Gastrointestinal and liver physiology - 15 Jul 2014
McIntosh Avery L, Huang Huan, Storey Stephen M, Landrock Kerstin K, Landrock Danilo, Petrescu Anca D, Gupta Shipra, Atshaves Barbara P, Kier Ann B, Schroeder Friedhelm
Abstract excerpt
Although human liver fatty acid-binding protein (FABP1) T94A variant has been associated with nonalcoholic fatty liver disease and reduced ability of fenofibrate to lower serum triglycerides (TG) to target levels, molecular events leading to this phenotype are poorly understood. Cultured primary hepatocytes from female human subjects expressing the FABP1 T94A variant exhibited increased neutral lipid (TG,...
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