Article
The human liver fatty acid binding protein T94A variant alters the structure, stability, and interaction with fibrates.
Biochemistry - 23 Dec 2013
Martin Gregory G, McIntosh Avery L, Huang Huan, Gupta Shipra, Atshaves Barbara P, Landrock Kerstin K, Landrock Danilo, Kier Ann B, Schroeder Friedhelm
Abstract excerpt
Although the human liver fatty acid binding protein (L-FABP) T94A variant arises from the most commonly occurring single-nucleotide polymorphism in the entire FABP family, there is a complete lack of understanding regarding the role of this polymorphism in human disease. It has been hypothesized that the T94A substitution results in the complete loss of ligand binding ability and function analogous to that seen...
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