Article
SPACA3 gene variants in a New Zealand cohort of infertile and fertile couples.
Human fertility (Cambridge, England) - 1 Jun 2014
Prendergast Deborah, Woad Kathryn J, Chamley Lawrence W, Holland Olivia J, Shelling Andrew N
Abstract excerpt
SPRASA (also referred to as SLLP1) is a protein identified in the acrosome of human sperm and encoded by the gene SPACA3. SPRASA is associated with sperm-oocyte recognition and binding, and may play a role in fertility. In order to determine whether variants in the SPACA3 gene are associated with human infertility, we undertook a genetic analysis of 102 infertile and 104 fertile couples. Three gene variants were...
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