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Article

In-Frame Variants in STAG3 Gene Cause Premature Ovarian Insufficiency

14 Nov 2019

Abstract excerpt

Primary ovarian insufficiency (POI) is a severe clinical syndrome deﬁned by ovarian dysfunction in women less than 40 years old who generally manifest with infertility, menstrual disturbance, raised gonadotrophins, and low oestradiol. STAG3 is considered a genetic aetiology of POI, which facilitates entry of REC8 into the nucleus of a cell and plays an essential role in gametogenesis. At present, only six...

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PMID: 31803224
DOI: 10.3389/fgene.2019.01016

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