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Article

Preimplantation Genetic Testing for Spastic Paraplegia Type 3.

Advances in experimental medicine and biology - 1 Jan 2021

Yapijakis Christos, Gintoni Iphigenia, Voumvourakis Costas, Chrousos George

Abstract excerpt

INTRODUCTION: Spastic paraplegia type 3 (SPG3) is a common autosomal dominant neurogenetic disease, presenting during childhood with symptoms of mildly progressive spasticity and weakness of the lower limbs. SPG3 develops due to mutations of the ATL1 gene that encodes atlastin-1, a GTPase crucial for the function of dendrites of corticospinal neurons. Here we present a case of preimplantation genetic testing for...

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PMID: 35023124
DOI: 10.1007/978-3-030-78787-5_42

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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