Article
Effects of the W153L substitution in HIV reverse transcriptase on viral replication and drug resistance to multiple categories of reverse transcriptase inhibitors.
Antimicrobial agents and chemotherapy - 1 Aug 2014
Xu Hong-Tao, Colby-Germinario Susan P, Oliveira Maureen, Rajotte Daniel, Bethell Richard, Wainberg Mark A
Abstract excerpt
A W153L substitution in HIV-1 reverse transcriptase (RT) was recently identified by selection with a novel nucleotide-competing RT inhibitor (NcRTI) termed compound A that is a member of the benzo[4,5]furo[3,2,d]pyrimidin-2-one NcRTI family of drugs. To investigate the impact of W153L, alone or in combination with the clinically relevant RT resistance substitutions K65R (change of Lys to Arg at position 65),...
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