Article
The M230L nonnucleoside reverse transcriptase inhibitor resistance mutation in HIV-1 reverse transcriptase impairs enzymatic function and viral replicative capacity.
Antimicrobial agents and chemotherapy - 1 Jun 2010
Xu Hong-Tao, Quan Yudong, Schader Susan M, Oliveira Maureen, Bar-Magen Tamara, Wainberg Mark A
Abstract excerpt
The M230L mutation in HIV-1 reverse transcriptase (RT) is associated with resistance to first-generation nonnucleoside reverse transcriptase inhibitors (NNRTIs). The present study was designed to determine the effects of M230L on enzyme function, viral replication capacity (RC), and the extent to which M230L might confer resistance to the second-generation NNRTI etravirine (ETR) as well as to the first-generation...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.