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Article

High Copy Numbers of β-Defensin Cluster on 8p23.1, Confer Genetic Susceptibility, and Modulate the Physical Course of Hidradenitis Suppurativa/Acne Inversa.

The Journal of investigative dermatology - 1 Aug 2016

Giamarellos-Bourboulis Evangelos J, Platzer Matthias, Karagiannidis Ioannis, Kanni Theodora, Nikolakis Georgios, Ulrich Jens, Bellutti Michael, Gollnick Harald, Bauer Michael, Zouboulis Christos C, Huse Klaus

Abstract excerpt

Hidradenitis suppurativa/acne inversa (HS) has a multifactorial pathogenesis, with many patients reporting positive family history. Nine β-defensin genes (among them DEFB4 and DEFB103, encoding for proinflammatory mediators human β-defensin-2 and human β-defensin-3, respectively) exist as a cluster (DEFB) affected by copy number (CN). We hypothesized that CNs are greater in patients with HS and that they are...

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PMID: 27164300
DOI: 10.1016/j.jid.2016.04.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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