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Article

Proteinuria Impairs Podocyte Regeneration by Sequestering Retinoic Acid

16 Aug 2013

Abstract excerpt

In CKD, the risk of kidney failure and death depends on the severity of proteinuria, which correlates with the extent of podocyte loss and glomerular scarring. We investigated whether proteinuria contributes directly to progressive glomerulosclerosis through the suppression of podocyte regeneration and found that individual components of proteinuria exert distinct effects on renal progenitor survival and...

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PMID: 23949798
DOI: 10.1681/asn.2012090950

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