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Article

Aberrant glycosylation and localization of polycystin-1 cause polycystic kidney in an AQP11 knockout model.

Journal of the American Society of Nephrology : JASN - 1 Dec 2014

Inoue Yuichi, Sohara Eisei, Kobayashi Katsuki, Chiga Motoko, Rai Tatemitsu, Ishibashi Kenichi, Horie Shigeo, Su Xuefeng, Zhou Jing, Sasaki Sei, Uchida Shinichi

Abstract excerpt

We previously reported that disruption of the aquaporin-11 (AQP11) gene in mice resulted in cystogenesis in the kidney. In this study, we aimed to clarify the mechanism of cystogenesis in AQP11(-/-) mice. To enable the analyses of AQP11 at the protein level in vivo, AQP11 BAC transgenic mice (Tg(AQP11)) that express 3×HA-tagged AQP11 protein were generated. This AQP11 localized to the endoplasmic reticulum (ER)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Kidney Tubules, Proximal

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Source

Open in PubMed Open full text

Identifiers

PMID: 24854278
DOI: 10.1681/ASN.2013060614
PMCID: PMC4243341

Genes

AQP11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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