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Article

Monogenic causes of non-obstructive azoospermia: challenges, established knowledge, limitations and perspectives.

Human genetics - 1 Jan 2021

Kasak Laura, Laan Maris

Abstract excerpt

It is estimated that one in 100 men have azoospermia, the complete lack of sperm in the ejaculate. Currently, ~ 20% of azoospermia cases remain idiopathic. Non-obstructive azoospermia (NOA) is mostly explained by congenital factors leading to spermatogenic failure, such as chromosome abnormalities. The knowledge of the monogenic causes of NOA is very limited. High genetic heterogeneity due to the complexity of...

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Identifiers

PMID: 31955275
DOI: 10.1007/s00439-020-02112-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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