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Article

Novel copy number variations within SYCE1 caused meiotic arrest and non-obstructive azoospermia.

BMC medical genomics - 19 Jun 2022

Huang Yuhua, Tian Ruhui, Xu Junwei, Ji Zhiyong, Zhang Yuxiang, Zhao Liangyu, Yang Chao, Li Peng, Zhi Erlei, Bai Haowei, Han Sha, Luo Jiaqiang, Zhao Jingpeng, Zhang Jing, Zhou Zhi, Li Zheng, Yao Chencheng

Abstract excerpt

BACKGROUND: Non-obstructive azoospermia (NOA) is the most severe disease in male infertility, but the genetic causes for majority of NOA remain unknown. METHODS: Two Chinese NOA-affected patients were recruited to identify the genetic causal factor of infertility. Whole-exome sequencing (WES) was conducted in the two patients with NOA. Sanger sequencing and CNV array were used to ascertain the WES results....

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Source

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Identifiers

PMID: 35718780
DOI: 10.1186/s12920-022-01288-8
PMCID: PMC9208180

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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