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Article

DNMT3L promotes quiescence in postnatal spermatogonial progenitor cells.

Development (Cambridge, England) - 1 Jun 2014

Liao Hung-Fu, Chen Wendy S C, Chen Yu-Hsiang, Kao Tzu-Hao, Tseng Yen-Tzu, Lee Chien-Yueh, Chiu Yu-Chiao, Lee Pei-Lung, Lin Qian-Jia, Ching Yung-Hao, Hata Kenichiro, Cheng Winston T K, Tsai Mong-Hsun, Sasaki Hiroyuki, Ho Hong-Nerng, Wu Shinn-Chih, Huang Yen-Hua, Yen Pauline, Lin Shau-Ping

Abstract excerpt

The ability of adult stem cells to reside in a quiescent state is crucial for preventing premature exhaustion of the stem cell pool. However, the intrinsic epigenetic factors that regulate spermatogonial stem cell quiescence are largely unknown. Here, we investigate in mice how DNA methyltransferase 3-like (DNMT3L), an epigenetic regulator important for interpreting chromatin context and facilitating de novo DNA...

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Share to Adult Stem Cells
Share to DNA (Cytosine-5-)-Methyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Extracellular Signal-Regulated MAP Kinases

Share to Proto-Oncogene Proteins c-akt

Share to Spermatogonia

Share to Testis

Share to Zinc Fingers

Source

Identifiers

PMID: 24850856
DOI: 10.1242/dev.105130

Genes

THY1
CDK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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