Article
Expression quantitative trait loci detected in cell lines are often present in primary tissues.
Human molecular genetics - 15 Nov 2009
Bullaughey Kevin, Chavarria Claudia I, Coop Graham, Gilad Yoav
Abstract excerpt
Expression quantitative trait loci (eQTL) mapping is a powerful tool for identifying genetic regulatory variation. However, at present, most eQTLs in humans were identified using gene expression data from cell lines, and it remains unknown whether these eQTLs also have a regulatory function in other expression contexts, such as human primary tissues. Here we investigate this question using a targeted strategy....
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