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Article

Mutant p53 regulates Dicer through p63-dependent and -independent mechanisms to promote an invasive phenotype.

The Journal of biological chemistry - 3 Jan 2014

Muller Patricia A J, Trinidad Antonio G, Caswell Patrick T, Norman Jim C, Vousden Karen H

Abstract excerpt

The control and processing of microRNAs (miRs) is critical in the regulation of all cellular responses. Previous studies have suggested that a reduction in the expression of certain miRs, or an overall decrease in miR processing through the partial depletion of Dicer, can promote enhanced metastatic potential. We show here that Dicer depletion can promote the invasive behavior of cells that is reflected in...

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Share to DEAD-box RNA Helicases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24220032
DOI: 10.1074/jbc.M113.502138
PMCID: PMC3879536

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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