Article
Interleukin-28 gene polymorphisms may contribute to HBsAg persistence and the development of HBeAg-negative chronic hepatitis B.
Liver international : official journal of the International Association for the Study of the Liver - 1 Mar 2015
Karataylı Senem C, Bozdayı Mithat, Karataylı Ersin, Öztürk Tuğba, Husseini Abbas A, Albayrak Rabia, Özkan Muhip, Kalaylıoğlu Zeynep, Yalçın Kendal, Çınar Kubilay, İdilman Ramazan, Yurdaydın Cihan
Abstract excerpt
BACKGROUND & AIMS: Aim of this study was to investigate whether a potential association exists between several single nucleotide polymorphisms (SNPs) of the IL-28B gene (rs12979860, rs1188122, rs8099917, rs8105790, rs12980275) and HBsAg persistence. Further, a potential effect on the development of HBeAg-negative CHB vs. inactive HBsAg carrier state was assessed in a genotype D HBV cohort. A cohort of chronic HDV...