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Article

Granulosa cell ligand NPPC and its receptor NPR2 maintain meiotic arrest in mouse oocytes.

Science (New York, N.Y.) - 15 Oct 2010

Zhang Meijia, Su You-Qiang, Sugiura Koji, Xia Guoliang, Eppig John J

Abstract excerpt

Granulosa cells of mammalian Graafian follicles maintain oocytes in meiotic arrest, which prevents their precocious maturation. We show that mouse mural granulosa cells, which line the follicle wall, express natriuretic peptide precursor type C (Nppc) messenger RNA (mRNA), whereas cumulus cells s...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Intercellular Signaling Peptides and Proteins

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Share to Receptors, Atrial Natriuretic Factor

Source

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Identifiers

PMID: 20947764
DOI: 10.1126/science.1193573
PMCID: PMC3056542

Genes

NPPC
NPR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20947764-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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