Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phosphoproteomic analysis of neoadjuvant breast cancer suggests that increased sensitivity to paclitaxel is driven by CDK4 and filamin A

7 Dec 2022

Abstract excerpt

Precision oncology research is challenging outside the contexts of oncogenic addiction and/or targeted therapies. We previously showed that phosphoproteomics is a powerful approach to reveal patient subsets of interest characterized by the activity of a few kinases where the underlying genomics is complex. Here, we conduct a phosphoproteomic screening of samples from HER2-negative female breast cancer receiving...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Cancer-related Molecular Pathways
Share to Microtubule and mitosis dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36477027
DOI: 10.1038/s41467-022-35065-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphoproteomic analysis of neoadjuvant breast cancer suggests that increased sensitivity to paclitaxel is driven by CDK4 and filamin APMID 36477027Read ↗

Pan-cancer proteogenomic investigations identify post-transcriptional kinase targetsSemantic proximity Read ↗

CDK4 phosphorylation status and a linked gene expression profile predict sensitivity to palbociclibSemantic proximity Read ↗

Mining the tumor phosphoproteome for cancer markers.Semantic proximity Read ↗

Targeting the Breast Cancer KinomeSemantic proximity Read ↗

Prospective pan-cancer phosphoproteomics at clinical scale extends therapeutic options in precision oncologySemantic proximity Read ↗

Phosphoproteomic analysis reveals PAK2 as a therapeutic target for lapatinib resistance in HER2-positive breast cancer cellsSemantic proximity Read ↗

Phosphoproteomic profiling of T cell acute lymphoblastic leukemia reveals targetable kinases and combination treatment strategiesSemantic proximity Read ↗

TOPAS: phosphoproteome data analysis and decision support platform for molecular tumor boardsSemantic proximity Read ↗

Comprehensive proteome, phosphoproteome and kinome characterization of luminal A breast cancerSemantic proximity Read ↗

Pim kinases in cancer: Diagnostic, prognostic and treatment opportunitiesSemantic proximity Read ↗

Multi-omic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradationSemantic proximity Read ↗

An oncogene addiction phosphorylation signature and its derived scores inform tumor responsiveness to targeted therapies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.