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Article

Genomic profile of pseudomyxoma peritonei analyzed using next-generation sequencing and immunohistochemistry.

International journal of cancer - 1 Mar 2015

Nummela Pirjo, Saarinen Lilli, Thiel Alexandra, Järvinen Petrus, Lehtonen Rainer, Lepistö Anna, Järvinen Heikki, Aaltonen Lauri A, Hautaniemi Sampsa, Ristimäki Ari

Abstract excerpt

Pseudomyxoma peritonei (PMP) is a relatively rare clinical syndrome characterized by neoplastic epithelial cells growing in the peritoneal cavity and secreting mucinous ascites. Our aim was to explore the molecular events behind this fatal but under-investigated disease. We extracted DNA from 19 appendix-derived PMP tumors and nine corresponding normal tissues, and analyzed the mutational hotspot areas of 48...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25274248
DOI: 10.1002/ijc.29245

Genes

BRAF
APC
GNAS
KRAS
MLH1
MSH2
MSH6
AKT1
SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Genomic profile of pseudomyxoma peritonei analyzed using next-generation sequencing and immunohistochemistry.PMID 25274248Read ↗

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Analysis of Mutation and Loss of Heterozygosity by Whole-Exome Sequencing Yields Insights into Pseudomyxoma Peritonei.Semantic proximity Read ↗

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