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Article

A novel selective broad-spectrum anti-DNA virus agent.

Nature - 1 Jan 2000

De Clercq E, Holý A, Rosenberg I, Sakuma T, Balzarini J, Maudgal P C

Abstract excerpt

A new compound has been found, (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine ((S)-HPMPA), that has potent and selective activity against a broad spectrum of DNA viruses, including herpes simplex virus (types 1 and 2); varicella zoster virus; thymidine kinase-deficient (TK-) mutants of herpes...

Topics

Adenine
Animals
Antiviral Agents
Chemical Phenomena
Chemistry
DNA Viruses
Herpes Simplex
Mice
Mutation
Organophosphonates
Organophosphorus Compounds
Rabbits

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Identifiers

PMID: 3762696
DOI: 10.1038/323464a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-3762696-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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