LAVR-289, an Acyclo-Nucleoside Phosphonate, Has Broad-Spectrum Activity against Herpesviruses

Abstract excerpt

Human herpesviruses are large dsDNA viruses that primarily cause opportunistic infections in healthy adults but can trigger life-threatening infections in immunocompromised patients. Previously, antivirals have been developed against a variety of herpesviruses; these include acyclovir for herpes simplex viruses (HSV1 and 2) and ganciclovir and letermovir for human cytomegalovirus (hCMV). However, broad-spectrum...