Article
KAY-2-41, a novel nucleoside analogue inhibitor of orthopoxviruses in vitro and in vivo.
Antimicrobial agents and chemotherapy - 1 Jan 2014
Duraffour Sophie, Drillien Robert, Haraguchi Kazuhiro, Balzarini Jan, Topalis Dimitri, van den Oord Joost J, Andrei Graciela, Snoeck Robert
Abstract excerpt
The availability of adequate treatments for poxvirus infections would be valuable not only for human use but also for veterinary use. In the search for novel antiviral agents, a 1'-methyl-substituted 4'-thiothymidine nucleoside, designated KAY-2-41, emerged as an efficient inhibitor of poxviruses. In vitro, KAY-2-41 was active in the micromolar range against orthopoxviruses (OPVs) and against the parapoxvirus...
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