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Article

Involvement of MAP3K8 and miR-17-5p in poor virologic response to interferon-based combination therapy for chronic hepatitis C.

PloS one - 1 Jan 2014

Tsubota Akihito, Mogushi Kaoru, Aizaki Hideki, Miyaguchi Ken, Nagatsuma Keisuke, Matsudaira Hiroshi, Kushida Tatsuya, Furihata Tomomi, Tanaka Hiroshi, Matsuura Tomokazu

Abstract excerpt

Despite advances in chronic hepatitis C treatment, a proportion of patients respond poorly to treatment. This study aimed to explore hepatic mRNA and microRNA signatures involved in hepatitis C treatment resistance. Global hepatic mRNA and microRNA expression profiles were compared using microarray data between treatment responses. Quantitative real-time polymerase chain reaction validated the gene signatures...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24819603
DOI: 10.1371/journal.pone.0097078
PMCID: PMC4018277

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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