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Article

Warfarin therapy--why one dose does not fit all!

The Journal of the Association of Physicians of India - 1 Aug 2013

Kulkarni Vrinda, Bhave Abhay, Munshi Renuka Kulkarni, Bhalerao Supriya, Bhattad Dhiraj, Khude Santosh, Upase Dnyneshwar

Abstract excerpt

We report an Indian adult female patient with Deep Vein Thrombosis (DVT), in whom it was difficult to achieve and maintain target INR on warfarin (oral anticoagulant) by conventional doses. Pharmacogenomics study for warfarin revealed that she had Homozygous mutant for CYP2C9 *3(CYP2C9 *3/*3) and Heterozygous mutant for VKORC 1(1639G >A) {genetic polymorphism double defect}. This conferred a greater sensitivity...

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PMID: 24818346

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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