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Article

γT -S195A thrombin reduces the anticoagulant effects of dabigatran in vitro and in vivo.

Journal of thrombosis and haemostasis : JTH - 1 Jul 2014

Sheffield W P, Lambourne M D, Eltringham-Smith L J, Bhakta V, Arnold D M, Crowther M A

Abstract excerpt

BACKGROUND: Dabigatran etexilate (DE) is an oral direct thrombin inhibitor used to prevent strokes in patients with atrial fibrillation. No licensed DE antidote is currently available. We hypothesized that active site-mutated S195A thrombin (S195A-IIa) and/or its trypsinized derivative (γT -S195A-IIa) would sequester dabigatran, the active form of DE, and reduce its anticoagulant effects. OBJECTIVE: To assess...

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PMID: 24815541
DOI: 10.1111/jth.12601

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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