Article
Effect of dabigatran on a prothrombinase-based assay for detecting activated protein C resistance: an ex vivo and in vitro study in normal subjects and factor V Leiden carriers.
Blood transfusion = Trasfusione del sangue - 1 Oct 2017
Gessoni Gianluca, Valverde Sara, Valle Letizia, Caruso Pierpaolo, Gessoni Francesca, Valle Roberto
Abstract excerpt
BACKGROUND: The aim of this study was to evaluate ex vivo and in vitro interference of a direct factor IIa inhibitor, dabigatran, on a prothrombinase-based assay to detect activated protein C resistance. MATERIALS AND METHODS: An ex vivo study was performed in six heterozygous factor V Leiden carriers and 12 normal subjects without the factor V Leiden mutation who were treated with dabigatran. An in vitro study...
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