Epigenetic-related gene expression profile in medullary thyroid cancer revealed the overexpression of the histone methyltransferases EZH2 and SMYD3 in aggressive tumours.

doi:10.1016/j.mce.2014.04.016

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Epigenetic-related gene expression profile in medullary thyroid cancer revealed the overexpression of the histone methyltransferases EZH2 and SMYD3 in aggressive tumours.

Molecular and cellular endocrinology - 5 Jul 2014

Sponziello Marialuisa, Durante Cosimo, Boichard Amelie, Dima Mariavittoria, Puppin Cinzia, Verrienti Antonella, Tamburrano Giulia, Di Rocco Giorgio, Redler Adriano, Lacroix Ludovic, Bidart Jean-Michel, Schlumberger Martin, Damante Giuseppe, Russo Diego, Filetti Sebastiano

Abstract excerpt

Epigenetic control of gene expression plays a major influence in the development and progression of many cancer types. Aim of the present study was to investigate the expression of epigenetic regulators in a large cohort of medullary thyroid carcinomas (MTC), correlating the data with the clinical outcome and mutational status of the patients. Taqman Low Density Arrays (TLDAs) were used to analyze expression...

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PMID: 24813658
DOI: 10.1016/j.mce.2014.04.016

Genes

SMYD3
RET

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