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Article

Epigenetic dysregulation of the IGF system in placenta of newborns exposed to maternal impaired glucose tolerance

1 Apr 2014

Abstract excerpt

AIMS: To determine whether placental IGF1R, IGFBP3, INSR and IGF1 DNA methylation and mRNA levels were dysregulated when exposed to maternal impaired glucose tolerance (IGT) and investigate whether the epigenetic profile is associated with feto-placental developmental markers. PATIENTS & METHODS: The IGT diagnosis was made according to the WHO criteria (IGT: n = 34; normal glucose tolerance [NGT]: n = 106). DNA...

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Identifiers

PMID: 24811788
DOI: 10.2217/epi.14.3

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