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Article

NBR1: The archetypal selective autophagy receptor

18 Oct 2022

Abstract excerpt

NBR1 was discovered as an autophagy receptor not long after the first described vertebrate autophagy receptor p62/SQSTM1. Since then, p62 has currently been mentioned in >10,000 papers on PubMed, while NBR1 is mentioned in <350 papers. Nonetheless, evolutionary analysis reveals that NBR1, and likely also selective autophagy, was present already in the last eukaryotic common ancestor (LECA), while p62 appears...

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PMID: 36255390
DOI: 10.1083/jcb.202208092

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