Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deletion of the MGMT gene in familial melanoma.

Genes, chromosomes & cancer - 1 Aug 2014

Appelqvist Frida, Yhr Maria, Erlandson Anna, Martinsson Tommy, Enerbäck Charlotta

Abstract excerpt

The DNA repair gene MGMT (O-6-methylguanine-DNA methyltransferase) is important for maintaining normal cell physiology and genomic stability. Alterations in MGMT play a critical role in the development of several types of cancer, including glioblastoma, lung cancer, and colorectal cancer. The purpose of this study was to explore the function of genetic alterations in MGMT and their connection with familial...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Modification Methylases
Share to DNA Repair Enzymes
Share to Gene Deletion

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Melanoma

Share to Melanoma, Cutaneous Malignant

Share to Skin Neoplasms

Share to Sweden

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 24801985
DOI: 10.1002/gcc.22180

Genes

MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deletion of the MGMT gene in familial melanoma.PMID 24801985Read ↗

A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma.Semantic proximity Read ↗

Novel O6-methylguanine-DNA methyltransferase SNPs: a frequency comparison of patients with familial melanoma and healthy individuals in Sweden.Semantic proximity Read ↗

Human melanoma genetics.Semantic proximity Read ↗

Melanoma in a patient with DNMT3A overgrowth syndrome.Semantic proximity Read ↗

Genetic variants in the folate metabolic pathway genes predict cutaneous melanoma-specific survival.Semantic proximity Read ↗

Common genetic variants of MUTYH are not associated with cutaneous malignant melanoma: application of molecular screening by means of high-resolution melting technique in a pilot case-control study.Semantic proximity Read ↗

The contribution of large genomic deletions at the CDKN2A locus to the burden of familial melanoma.Semantic proximity Read ↗

Genetic analysis of the GRM1 gene in human melanoma susceptibility.Semantic proximity Read ↗

Germline rearrangements in families with strong family history of glioma and malignant melanoma, colon, and breast cancer.Semantic proximity Read ↗

Polymorphisms of the FAS and FAS ligand genes associated with risk of cutaneous malignant melanoma.Semantic proximity Read ↗

Blood DNA methylation, nevi number, and the risk of melanoma.Semantic proximity Read ↗

Deletion mapping suggests that the 1p22 melanoma susceptibility gene is a tumor suppressor localized to a 9-Mb interval.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.