Article
Common genetic variants of MUTYH are not associated with cutaneous malignant melanoma: application of molecular screening by means of high-resolution melting technique in a pilot case-control study.
The International journal of biological markers - 1 Jan 2000
Santonocito Concetta, Paradisi Andrea, Capizzi Rodolfo, Torti Eleonora, Lanza-Silveri Sara, Penitente Romina, Zuppi Cecilia, Capoluongo Ettore
Abstract excerpt
MUTYH glycosylase recognizes the 8-oxoG:A mismatch and is able to excise the adenine base using proofreading mechanisms. Some papers have reported a strong association between cancer development or aggressiveness and MUTYH gene mutations. The aim of this study was to find a possible association between the most frequent MUTYH mutations and melanoma in the context of a case-control pilot study. One hundred...
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