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Overexpression of miR‐483‐5p/3p cooperate to inhibit mouse liver fibrosis by suppressing the <scp>TGF</scp>‐β stimulated <scp>HSC</scp>s in transgenic mice

6 May 2014

Abstract excerpt

The transition from liver fibrosis to hepatocellular carcinoma (HCC) has been suggested to be a continuous and developmental pathological process. MicroRNAs (miRNAs) are recently discovered molecules that regulate the expression of genes involved in liver disease. Many reports demonstrate that miR-483-5p and miR-483-3p, which originate from miR-483, are up-regulated in HCC, and their oncogenic targets have been...

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PMID: 24801603
DOI: 10.1111/jcmm.12293

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