Article
Drosophila Valosin-Containing Protein is required for dendrite pruning through a regulatory role in mRNA metabolism.
Proceedings of the National Academy of Sciences of the United States of America - 20 May 2014
Rumpf Sebastian, Bagley Joshua A, Thompson-Peer Katherine L, Zhu Sijun, Gorczyca David, Beckstead Robert B, Jan Lily Yeh, Jan Yuh Nung
Abstract excerpt
The dendritic arbors of the larval Drosophila peripheral class IV dendritic arborization neurons degenerate during metamorphosis in an ecdysone-dependent manner. This process-also known as dendrite pruning-depends on the ubiquitin-proteasome system (UPS), but the specific processes regulated by the UPS during pruning have been largely elusive. Here, we show that mutation or inhibition of Valosin-Containing...
Topics
- Adenosine Triphosphatases
- Animals
- DNA-Binding Proteins
- Dendrites
- Drosophila Proteins
- Drosophila melanogaster
- Ecdysone
- Gene Expression Regulation
- Mutation
- Neurons