Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Whole-animal genome-wide RNAi screen identifies networks regulating male germline stem cells in Drosophila.

Nature communications - 3 Aug 2016

Liu Ying, Ge Qinglan, Chan Brian, Liu Hanhan, Singh Shree Ram, Manley Jacob, Lee Jae, Weideman Ann Marie, Hou Gerald, Hou Steven X

Abstract excerpt

Stem cells are regulated both intrinsically and externally, including by signals from the local environment and distant organs. To identify genes and pathways that regulate stem-cell fates in the whole organism, we perform a genome-wide transgenic RNAi screen through ubiquitous gene knockdowns, focusing on regulators of adult Drosophila testis germline stem cells (GSCs). Here we identify 530 genes that regulate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Lineage
Share to Gene Knockdown Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Insect

Share to Genome, Insect

Share to Germ Cells

Share to High-Throughput Screening Assays

Share to Organ Specificity

Share to Stem Cell Niche

Source

Open in PubMed Open full text

Identifiers

PMID: 27484291
DOI: 10.1038/ncomms12149
PMCID: PMC4976209

Genes

GSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Whole-animal genome-wide RNAi screen identifies networks regulating male germline stem cells in Drosophila.PMID 27484291Read ↗

Decoding the regulatory logic of the <i>Drosophila</i> male stem cell systemSemantic proximity Read ↗

Stonewall prevents expression of testis-enriched genes and binds to insulator elements in <i>D. melanogaster</i>Semantic proximity Read ↗

Chromatin and gene expression changes during female Drosophila germline stem cell development illuminate the biology of highly potent stem cellsSemantic proximity Read ↗

A Targeted RNAi Screen Reveals Drosophila Female-Sterile Genes That Control the Size of Germline Stem Cell Niche During Development.Semantic proximity Read ↗

Genome-wide RNAi screen identifies networks involved in intestinal stem cell regulation in Drosophila.Semantic proximity Read ↗

Epigenetic regulation of stem cell maintenance in the Drosophila testis via the nucleosome-remodeling factor NURF.Semantic proximity Read ↗

The <i>Drosophila</i> histone methyl-transferase SET1 coordinates multiple signaling pathways in regulating male germline stem cell maintenance and differentiationSemantic proximity Read ↗

An ancient split of germline and somatic stem cell lineages in HydraSemantic proximity Read ↗

Integrative epigenomic analysis reveals unique epigenetic signatures involved in unipotency of mouse female germline stem cellsSemantic proximity Read ↗

A single cell atlas reveals unanticipated cell type complexity in <i>Drosophila</i> ovariesSemantic proximity Read ↗

Escargot restricts niche cell to stem cell conversion in the Drosophila testis.Semantic proximity Read ↗

Stonewalling Drosophila stem cell differentiation by epigenetic controls.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.