Article
Clinical relevance of sensitive and quantitative STAT3 mutation analysis using next-generation sequencing in T-cell large granular lymphocytic leukemia.
The Journal of molecular diagnostics : JMD - 1 Jul 2014
Kristensen Thomas, Larsen Martin, Rewes Annika, Frederiksen Henrik, Thomassen Mads, Møller Michael Boe
Abstract excerpt
Diagnosis of T-cell large granular lymphocytic leukemia (T-LGL) is often challenging because clinical and laboratory characteristics are overlapping with nonneoplastic conditions. Recently, mutation in the STAT3 gene has been identified as a recurrent genetic abnormality in T-LGL. STAT3 mutation, therefore, represents a promising marker in T-LGL diagnostics. We developed a new quantitative next-generation...
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