Genome-wide association study identifies variants in casein kinase II (CSNK2A2) to be associated with leukocyte telomere length in a Punjabi Sikh diabetic cohort.

doi:10.1161/CIRCGENETICS.113.000412

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Article

Genome-wide association study identifies variants in casein kinase II (CSNK2A2) to be associated with leukocyte telomere length in a Punjabi Sikh diabetic cohort.

Circulation. Cardiovascular genetics - 1 Jun 2014

Saxena Richa, Bjonnes Andrew, Prescott Jennifer, Dib Patrick, Natt Praveen, Lane Jacqueline, Lerner Megan, Cooper Jackie A, Ye Yuanqing, Li Ka Wah, Maubaret Cécilia G, Codd Veryan, Brackett Daniel, Mirabello Lisa, Kraft Peter, Dinney Colin P, Stowell Donald, Peyton Marvin, Ralhan Sarju, Wander Gurpreet S, Mehra Narinder K, Salpea Klelia D, Gu Jian, Wu Xifeng, Mangino Massimo, Hunter David J, De Vivo Immaculata, Humphries Steve E, Samani Nilesh J, Spector Tim D, Savage Sharon A, Sanghera Dharambir K

Abstract excerpt

BACKGROUND: Telomere length is a heritable trait, and short telomere length has been associated with multiple chronic diseases. We investigated the relationship of relative leukocyte telomere length with cardiometabolic risk and performed the first genome-wide association study and meta-analysis to identify variants influencing relative telomere length in a population of Sikhs from South Asia. METHODS AND...

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PMID: 24795349
DOI: 10.1161/CIRCGENETICS.113.000412
PMCID: PMC4106467

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